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- A love story between a couple, Cara and Jagger. Cara has a special condition of super sharp memory that makes her remember the details of events. Jagger, on the other hand, is Cara's ex-boyfriend who has amnesia. Cara is then hired by Jagger's grandfather to care for him and make him remember things about his past.
- Brotherhood has never been smooth for Sam (Alden Richards) and Onyok (Paolo Ballesteros) as they have always disdained each other. In the turn of events, Sam was told that their mother was hospitalized. He had no choice but to bring his brother back home. But in a more trying twist of fate, Sam discovers that Onyok has taken a different path that is even harder to accept - to become a woman and change his name to Sophia. How will Sam and Sophia come to terms with their seemingly irreconcilable differences as siblings?
- For a prisoner like Argel "Boy Pitik" Corpus (Dingdong Dantes), hoping is futile. He was a lookout in a bank robbery that ended up in a chilling loss of innocent lives. He has become aloof, and unlike the other detainees, he never had any visitor. Argel religiously dials 1430 and pretends to be talking to a person on the other line. In reality, it's just a dial tone. But one day, someone suddenly speaks on the other end of the line. How can one voice spark change and hope in the life of a convicted criminal?
- A retired school teacher on the verge of senility finds difficulty in connecting with her grandson, who is now taking care of her.
- What started out as the bride's accidental dropping of a wine glass cast a dark shadow upon the seemingly perfect couple Jean (Jennylyn Mercado) and Martin (Tom Rodriguez). Jean is diagnosed with a medical condition known as Amyotrophic Lateral Sclerosis (ALS) which has become too aggressive for her to deal with alone. She starts to conceal her physical difficulties by being hostile to the people who cares about her. How will Jean and Martin deal with a crippling disease that threatens not only to debilitate Jean, but eventually destroy her relationship with Martin?