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- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoA woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- CreatorShonda RhimesMichelle LirtzmanStarsEllen PompeoChandra WilsonJames Pickens Jr.A drama centered on the personal and professional lives of five surgical interns and their supervisors.
- CreatorI. Marlene KingStarsTroian BellisarioAshley BensonLucy HaleFour friends band together against an anonymous foe who threatens to reveal their darkest secrets, while also investigating the disappearance of their best friend.
- CreatorJulie PlecKevin WilliamsonStarsNina DobrevPaul WesleyIan SomerhalderThe lives, loves, dangers and disasters in the town, Mystic Falls, Virginia. Creatures of unspeakable horror lurk beneath this town as a teenage girl is suddenly torn between two vampire brothers.
- CreatorJosh SchwartzStarsMischa BartonAdam BrodyPeter GallagherA troubled youth becomes embroiled in the lives of a close-knit group of people in the wealthy, upper-class neighborhood of Newport Beach, Orange County, California.
- CreatorCarter BaysCraig ThomasStarsJosh RadnorJason SegelCobie SmuldersA father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- CreatorPaul T. ScheuringStarsDominic PurcellWentworth MillerAmaury NolascoA structural engineer installs himself in a prison he helped design, in order to save his falsely accused brother from a death sentence by breaking themselves out from the inside.
- CreatorDarren StarJeff JudahGabe SachsStarsShenae Grimes-BeechTristan Mack WildsAnnaLynne McCordA Kansas family relocates to Beverly Hills, where their two children adapt to the infamous social drama of West Beverly Hills High.
- CreatorStephanie SavageJosh SchwartzStarsBlake LivelyLeighton MeesterPenn BadgleyPrivileged teens living on the Upper East Side of New York can hide no secret from the ruthless blogger who is always watching.
- CreatorWhitney CummingsMichael Patrick KingStarsKat DenningsBeth BehrsGarrett MorrisTwo young women waitressing at a greasy spoon diner strike up an unlikely friendship in the hopes of launching a successful business - if only they can raise the cash.
- CreatorDan BerendsenStarsSkyler SamuelsGracie GillamKi Hong LeeA girl with special cat-like powers is being hunted by an assassin.
- CreatorDavid ShoreStarsHugh LaurieOmar EppsRobert Sean LeonardUsing a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- CreatorTracy GambleStarsKatey SagalKaley CuocoAmy DavidsonThe Hennessy clan -- mother Cate, daughters Bridget and Kerry, and son Rory -- look to one another for guidance and support after the death of Paul, the family patriarch. Cate's parents lend a hand.
- CreatorMark SchwahnStarsChad Michael MurrayJames LaffertyHilarie Burton MorganHalf-brothers Lucas and Nathan Scott trade between kinship and rivalry both on the basketball court and in the hearts of their friends in the small, but not so quiet town of Tree Hill, North Carolina.
- CreatorDarren StarStarsSarah Jessica ParkerKim CattrallKristin DavisFour female New Yorkers gossip about their sex lives (or lack thereof) and find new ways to deal with being a woman in the late 1990s.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorBonnie TurnerTerry TurnerStarsJohn LithgowJane CurtinKristen JohnstonA group of aliens is sent to Earth, disguised as a human family, to experience and report life on the third planet from the sun.
- CreatorShannon FarrJohn MurrayStarsSteve ByersJennifer KyddEphraim EllisFalcon Beach is a town in cottage country by a lake in Canadian province Manitoba, where aquatic sports are part of the pleasure package which attracts many visitors during the sunny tourist season. Local adolescent blond god Jason Tanner, who runs the barely break-even marina with his widowed ma, and his best friend Danny, whose family owns an old-fashioned arcade, are content with their simple life, but everything starts changing when the Bradshaw family returns to a cabin it owns there, as dad Trevor, a New York corporate tycoon, hatches plans to 'develop' the paradise profitably, never mind environment or locals. His daughter Paige, a Harvard brain, will date every attractive male in the story and cause them mixed emotions, while her brother Lane sways even more between dad's ruthless enterprise and his own drug addiction and dealings with murky Mook, fighting each-other and the police. Danny's relationship with local life-guard and hip hop-coach Erin also has extreme heights and lows.
- CreatorTracy NewmanJonathan StarkStarsJim BelushiCourtney Thorne-SmithLarry Joe CampbellA television show centered around a macho everyman, his loving wife, and their three precocious children.
- StarsRobert BuckleyJoel BertiNatalie MartinezSet in the world of the cutthroat fashion industry, a ruthless mogul (Derek) defends her company against a hostile takeover.
- CreatorJon Harmon FeldmanStarsEliza DushkuShawn ReavesZach GalifianakisA university graduate working in the city morgue is able to repeat the same day over again to prevent murders or other disasters.
- CreatorMark BrazillBonnie TurnerTerry TurnerStarsTopher GraceLaura PreponMila KunisA comedy revolving around a group of teenage friends, their mishaps, and their coming of age, set in 1970s Wisconsin.
- CreatorJosh AppelbaumAndré NemecScott RosenbergStarsBryan GreenbergLaura PreponWarren ChristieBest-selling author Nick Garrett hopes to get over his writer's block by going back to his hometown of Knights Ridge, Mass. There, he realizes he's got to finally face the people he wrote about unfavorably in his novel.
- CreatorHart HansonStarsEmily DeschanelDavid BoreanazMichaela ConlinF.B.I. Special Agent Seeley Booth teams up with the Jeffersonian's top anthropologist, Dr. Temperance Brennan, to investigate cases where all that's left of the victims are their bones.
- CreatorJoss WhedonStarsSarah Michelle GellarNicholas BrendonAlyson HanniganA young woman, destined to slay vampires, demons and other infernal creatures, deals with her life fighting evil, with the help of her friends.