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- DirectorMax MayerStarsHugh DancyRose ByrnePeter GallagherAdam, a lonely man with Asperger's Syndrome, develops a relationship with his upstairs neighbor, Beth.
- DirectorKaran JoharStarsShah Rukh KhanKajolSheetal MenonAn Indian Muslim man with Asperger's syndrome takes a challenge to speak to the President of the United States seriously and embarks on a cross-country journey.
- DirectorMick JacksonStarsClaire DanesJulia OrmondDavid StrathairnA biopic of Temple Grandin, an autistic woman who has become one of the top scientists in the humane livestock handling industry.
- DirectorMarc EvansStarsAlan RickmanSigourney WeaverCarrie-Anne MossA drama focused on the friendship between a high-functioning autistic woman and a man who is traumatized after a fatal car accident.
- DirectorElissa DownStarsRhys WakefieldLuke FordToni ColletteAll Thomas wants is a normal adolescence but his autistic brother, Charlie, thwarts his every opportunity. Will Thomas, with the help of his girlfriend, Jackie, accept his brother?
- DirectorPetter NæssStarsJosh HartnettRadha MitchellGary ColeA love story between two savants with Asperger's syndrome, a kind of autism, whose conditions sabotage their budding relationship.
- DirectorJanet GrilloStarsBeth BroderickAshley RickardsAramazd StepanianThe story of Jeanne and her autistic teenage daughter, Mandy. Jeanne has cared for Mandy since the day she was born, growing closer every day to a child who is charmingly offbeat one moment and nearly impossible to manage the next.
- DirectorMichael Ray FoxStarsRhys Bevan-JohnChristina CuffariCory BowlesA socially introverted game designer named William Borchert has barely left his house in years. Once reunited with Olivia, the girl he had loved since high school, he fights to live with his condition of undiagnosed Autism and to form a hopeful future.
- DirectorYoon-Chul JungStarsCho Seung-wooKim Mi-sookLee Ki-youngAn autistic boy discovers he has a talent for running and with the help of the mother participates in a major marathon.
- DirectorRob BrownStarsAndrew ScottGeorgia GroomeAntonia Campbell-HughesAn autistic man and woman's friendship becomes tested when a 15-year old girl comes between them.
- DirectorLasse HallströmStarsEwan McGregorEmily BluntAmr WakedA fisheries expert is approached by a consultant to help realize a sheik's vision of bringing the sport of fly-fishing to the desert and embarks on an upstream journey of faith and fish to prove the impossible possible.
- DirectorRob BurnettStarsCraig RobertsPaul RuddSelena GomezA man suffering a family loss enrolls in a class about care-giving that changes his perspective on life.
- DirectorShonali BoseNilesh ManiyarStarsKalki KoechlinRevathiSayani GuptaA rebellious young woman with cerebral palsy leaves her home in India to study in New York, unexpectedly falls in love, and embarks on an exhilarating journey of self-discovery.
- DirectorBen LewinStarsJohn HawkesHelen HuntWilliam H. MacyA man in an iron lung who wishes to lose his virginity contacts a professional sex surrogate with the help of his therapist and priest.
- DirectorMarti NoxonStarsRebekah KennedyLily CollinsDana L. WilsonA young woman, dealing with anorexia, meets an unconventional doctor who challenges her to face her condition and embrace life.
- DirectorDamien O'DonnellStarsJames McAvoySteven RobertsonRomola GaraiWhen the kinetic Rory moves into his room in the Carrigmore Residential Home for the Disabled, his effect on the home is immediate. Most telling is his friendship with Michael, a young man with cerebral palsy and nearly unintelligible speech. Somehow, Rory understands Michael, and encourages him to experience life outside the confines of home.
- DirectorJulian SchnabelStarsMathieu AmalricEmmanuelle SeignerMarie-Josée CrozeThe true story of Elle editor Jean-Dominique Bauby who suffers a stroke and has to live with an almost totally paralyzed body; only his left eye isn't paralyzed.
- DirectorAndrzej JakimowskiStarsEdward HoggAlexandra Maria LaraMelchior DerouetA blind teacher breaks the rules to help a female student rediscover the pleasures of life.
- DirectorSanjay Leela BhansaliStarsAmitabh BachchanRani MukerjiShernaz PatelThe cathartic tale of a young woman who can't see, hear, or speak, and the teacher who brings a ray of light into her dark world.
- DirectorXiaolu XueStarsJet LiZhang WenGwei Lun-MeiExplores the subject of parental love and autism in kids.
- DirectorIan FitzgibbonStarsThomas Brodie-SangsterLilly ForgáchIan FitzgibbonA dying 15-year-old boy draws stories of an invincible superhero as he struggles with his mortality.
- DirectorSean McNamaraStarsAnnaSophia RobbDennis QuaidHelen HuntBethany Hamilton, a professional surfer, loses her left arm in a shark attack. Unwilling to pay attention to the gravity of her situation, Bethany decides to get back into the ocean and surf again.
- DirectorLars von TrierStarsEmily WatsonStellan SkarsgårdKatrin CartlidgeOilman Jan is paralyzed in an accident. His wife, who prayed for his return, feels guilty; even more, when Jan urges her to have sex with another.
- DirectorEskil VogtStarsEllen Dorrit PetersenHenrik RafaelsenVera VitaliForsaken in a new Oslo apartment, a frail blind woman battles to come to terms with her condition, as she slowly retracts into an elaborate fantasy bubble. Are her stories fanning her suspicions, or is this what total blindness looks like?
- DirectorGeorge C. WolfeStarsHilary SwankEmmy RossumJosh DuhamelA drama centered on a classical pianist who has been diagnosed with ALS and the brash college student who becomes her caregiver.
- DirectorJessica HausnerStarsSylvie TestudLéa SeydouxBruno TodeschiniIn order to escape her isolation, wheelchair-bound Christine makes a life changing journey to Lourdes, the iconic site of pilgrimage in the Pyrenees Mountains.