- Originally cast as a guest star on the pilot of Boy Meets World (1993). The actress who was cast as Topanga Lawrence was not working out. She and another girl were asked to read on the spot. Danielle won the role.
- Claims that she and Ben Savage went on exactly one date, while filming Boy Meets World (1993) (1993-2000), and that, by the end of the date, they both decided that they would just stay friends.
- Revealed in an interview with a L.A. radio station that a former boyfriend, who was an actor and whom she dated almost 10 years prior, physically abused her (2008).
- Her 2013 wedding was said to be attended by fellow actors Ben Savage, Jonathan Taylor Thomas, Matthew Lawrence and Betsy Randle.
- (December 20, 2007) Arrested in Newport Beach, California on a drunken driving warrant and released from jail shortly after her arrest.
- Lost 27 pounds on the Nutrisystem diet. After she revealed this on television, Nutrisystem contracted her to be a spokesperson for their company.
- Ranked #69 on Maxim's "Hot 100" of 2014 list.
- Attended high school (Calabasas High School) prom with Lance Bass.
- Mixed up dates for her wedding to interfere with friend and fellow Boy Meets World (1993) actor Rider Strong, they ended up getting married on the same weekend. Splitting up the cast. Half going to Rider's, half to Danielle's.
- Brave New World: Part 2 (2000), the series finale of Boy Meets World (1993), aired on her 19th birthday: May 5, 2000.
- Since becoming a Boy Meets World (1993) regular, she has had her own website, magazine column, calendar, poster, and in-line skating video ("Grinders in Line", which she made with BMW co-star Rider Strong).
- She got married only one day before her Boy Meets World (1993) co-star Rider Strong.
- Was chosen as one of Teen People magazine's 21 of the hottest stars under 21.
- (October 19, 2013) Married her boyfriend of 4 years Tim Belusko following a 17-month-long engagement.
- Her father, Rick, is a medical equipment sales executive. Her mother, Jennifer, manages Danielle's career.
- Celebrity spokesperson for Nutrisystem diet foods. (August 2007)
- Her father has English, German, Irish and Scottish ancestry. Her mother is of Maltese ancestry.
- Currently living in Orange County, California (July 2006)
- Auditioned for the role of Kim in the adventure film Flipper (1996), but was turned down.
- Serves as a special contributor to The Tyra Banks Show (2005).
- Mother, with husband Jensen Karp, of sons Adler Lawrence Karp (b. June 24, 2019) and Keaton Joseph Karp (b. August 29, 2021).
- Owns 130 pairs of shoes.
- Has a younger brother: Christopher Fishel.
- Auditioned for a role in Cabin Fever (2002) in which her former Boy Meets World (1993) co-star Rider Strong starred in.
- Her son Adler's middle name Lawrence was chosen in honor of Fishel's own father, who died 11 months prior.
- Her son Adler was born 4 weeks early.
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