- As a child, she lived across the street from Adriana Caselotti, the voice of Snow White. Mary Kay would eventually take over as Snow White's voice for read-along books and commercials after Adriana retired.
- Gained popularity for voicing most of the female characters on the TV show South Park (1997) (Stan's, Kenny's, and Cartman's mothers, Wendy Testaburger, Mayor McDaniels, Ms. Crabtree, Principal Victoria, Stan's sister Shelly, and Nurse Gollum).
- Suffered from lifelong depression nobody knew of until after she committed suicide.
- Was the original voice for Timmy Turner in the The Fairly OddParents (2001)'s "Oh Yeah! Cartoons" shorts. Upon her death, Tara Strong (then Charendoff) took over the role.
- Died of a self-inflicted gunshot wound to the head.
- With a total of eleven, Mary Kay holds the distinction of voicing the most characters in the original Leisure Suit Larry game series.
- She was a Trekkie and when she was a child, she and her mother wrote letters to NBC to try and keep the original Star Trek TV show on the air for a third season. She also enjoyed attending Star Trek conventions and was a self-proclaimed, 'geek'.
- First job was a radio commercial for a small home security company on a local radio station back in 1986.
- Was a close friend of Grey Griffin, who took over voicing Daphne in further Scooby-Doo productions.
- She has appeared in one film that has been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Beauty and the Beast (1991).
- Her family were Jewish emigrants from Germany, the Netherlands, and England. Her mother's surname was originally Enoch.
- She was the second cousin, three times removed, of Samuel Gompers, a cigar maker, labor union leader, and a key figure in American labor history, who founded the AFL (American Federation of Labor).
- She never had any children during her marriage with Dino Andrade.
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