- Her father was John Vachon, a photographer during and after World War II.
- She is known for producing quirky, cutting edge films with emerging performers and directors. Several of her films, including Kids (1995) and Boys Don't Cry (1999), were considered quite controversial upon release.
- Named one of her production companies Killer Films. She wrote a book on low budget film production called "Shooting to Kill".
- Ranked #46 of 50 influential people in The New York Observer's "The New Power Gays" article, June 2011.
- Adopted daughter's full name is Guthrie Forest Yi Wen Yi McCarty Vachon.
- Member of the jury at the Venice Film Festival in 2005.
- Was member of the dramatic jury at the Sundance Film Festival in 1993.
- Was member of the dramatic jury at the Sundance Film Festival in 2005.
- Member of the jury at the Sarajevo Film Festival in 2010.
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