- Brother of theatrical actor, stage manager, director, playwright and producer Victor Wolfson.
- Father: Adolph Wolfson; Mother: Rebecca Hochstein.
- Originally a medical student at the University of Moscow, Wolfson switched to drama after witnessing an autopsy as part of his training. His medical background influenced the television roles he was offered.
- Wolfson was blacklisted from Broadway roles during the McCarthy communist witch hunt era due to Wolfson's socialist political leanings.
- His best friend was actor John Randolph.
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