- Left first husband, Broadway theater scion Eric Nederlander, for Jerry Seinfeld just weeks after their wedding.
- Has 3 children with husband Jerry Seinfeld: a daughter Sascha, born November 7, 2000; a son Julian Kal, born March 1, 2003; and a son Shepherd Kellen, born August 22, 2005. All were born in New York City.
- Legally changed her first name from Nina to Jessica (25 September 1995)
- Founder and president of Baby Buggy, a non-profit corporation.
- Grew up in Burlington, Vermont, where her father designs computer systems and databases, and her mother works for the Department of Corrections.
- Is friends with Madonna.
- Graduated from the University of Vermont.
- Release of her book, "Deceptively Delicious: Simple Secrets to Get Your Kids Eating Good Foods". (2007)
- Sister-in-law of Carolyn Liebling.
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