- She and her mother Katie Holmes escaped from Scientology after it was revealed that Suri would be alienated from her mother for 6 weeks on a cruise ship; her mother objected to this and the two of them left Scientology.
- Her parents are Tom Cruise and Katie Holmes.
- She was born on the same day and in the same hospital as Brooke Shields's daughter Grier Henchy. Her father Tom had famously feuded with Shields three years earlier after she gave birth to her first daughter Rowan.
- Only biological child of Tom Cruise and Katie Holmes.
- Has two adopted older half-siblings, Isabella and Connor Cruise, whom her father Tom Cruise adopted with his second wife, actress Nicole Kidman.
- In 2005, the Golden Raspberry Awards introduced a special category called "Most Tiresome Tabloid Targets," which was awarded to "Tom Cruise, Katie Holmes, Oprah Winfrey's couch, the Eiffel Tower, and 'Tom's baby,'" referring to Suri. Suri was born a month after the ceremony, making her the first (and as of 2022, only) person to win a Razzie before birth.
- She was born at St. John's Health Center in Santa Monica, at 3:26 am PST. Weighed 7 lbs. 7 oz. and was 20 inches.
- Granddaughter of Thomas Cruise Mapother III (1934-1984), Mary Lee (née Pfeiffer) (1936-2017), Martin Joseph Holmes, Sr., and Kathleen Ann (Craft).
- Niece of Marian Henry (nee Mapother), Lee Anne De Vette, Cass Mapother, Tamera Jean Holmes (b. 1967), Holly Ann Holmes (b. 1969), Nancy Kay Holmes (b. 1974), and Martin Joseph Holmes, Jr. (b. 1970).
- Cousin of Adem Darmody and Liam Darmody.
- First cousin once removed of character actor William Mapother, her father Tom Cruise's cousin.
- Suri began listing her name publicly as "Suri Noelle". Suri wasn't given a middle name at birth; however, "Noelle" is her mother Katie Holmes' middle name. (2024)
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