According to Kirstie Alley in her memoir, she fell in love with John Travolta during filming, but she stayed faithful to her husband.
Of all the roles he's played, John Travolta said the character he plays in this film is the most like his real personality.
Mollie's two blind dates that she imagines as Mikey's father are listed in the credits as "Mr. Impatient" and "Mr. Anal".
John Travolta said this was the only time, after watching a premiere of his, that he knew he was going to be in a major hit.
Amy Heckerling was inspired to write the film after her husband and writer Neal Israel started playfully talking in a different voice to pretend what their new baby would say. Her husband also has a cameo as Kirstie Alley's character's boss.