It's unlikely. However, both Shameless and The Simpsons are comedy series that centers around dysfunctional families and other dysfunctional and quirky character whom live in the same city or town. Both Homer Simpson and Frank Gallagher shames a couple of similarities as they are bearded and they get drunk, they are selfish, careless, neglectful and are abusive. Although The Simpsons didn't inspire Shameless and is not a live action remake of the long-running animated comedy. Shameless still could be a live action British version of The Simpsons.