This is the second episode that shows two people sharing the same bed together on television, something unusual at the time. The first was Person or Persons Unknown (1962). Due to censorship regulations from the networks, TV shows at the time would portray married couples sleeping on separate beds. In both of these cases, the couples were still fully dressed and had gone to sleep while drunk, thus making it clear to the viewer they hadn't "slept" together.
The bulletin board in front of the church says that the sermon will be given by Rev. Kogh Gleason. F. Keogh Gleason was a set decorator at M-G-M for many years, and worked on The Twilight Zone (1959).
The abandoned town in which the Frazers find themselves is the same location used for The Monsters Are Due on Maple Street (1960) among countless other episodes. As the actors move through the 'town,' they traverse some of the old themed 'street' sets which were then standing on the old MGM backlot, including the New England Street (aka Andy Hardy Street), the Small Town Street that connects to it, and the small train depot that faces it. During the closing credits the whole section can been seen as an L-shape in the background.
Nancy Malone, who plays the wife, Millie, went on to become the first female vice-president of Television at 20 Century Fox.
This story is one of two Twilight Zone stories mentioned in the song "The Twilight Zone" by the rock band Rush on their 2112 album. However, they changed the gender of the child to a boy, presumably so that it would rhyme with "toy."