This episode again reinforces that Team Rocket know they are in a TV show when they say "We have to fill a half-hour." They also break the fourth wall when they say they came early because of the "time constraints" on the show.
First appearance of Psyduck.
The Pokemon Lovers Club is probably based on the Pokémon Fan Club from the game.
Pokémonitis is believing you are a Pokémon.
Nurse Joy's cross is pink and Officer Jenny's symbol is an inverted chevron.