"Stimpy's Invention" is the first time where Billy West provides vocals for Ren. Ren's maniacal cackling was provided by West, who would later take over the role of Ren for the last few seasons.
In "Stimpy's Invention", folksinger Stinky Wizzleteats is a caricature of folksinger Burl Ives. The song "Happy Happy Joy Joy" contains numerous quotes from Ives' performance in The Big Country (1958).
In "Stimpy's Invention", Stimpy was originally supposed to lick his underwear after Ren ironed it, but Nick took it out.
In "Stimpy's Invention", The turntable Stimpy plays the "Happy Happy Joy Joy" record on is an old "Close N' Play" phonograph, a record player built for children to play 45-RPM records automatically when you close the lid which has the needle on top.
Bob Jaques flew to Fil-Cartoons in the Philippines to oversee the ink and paint for "Stimpy's Invention" after seeing their work on "Fire Dogs", which he thought was substandard. It is because of his proactive actions that the cartoon came out looking as good as it did.