The first 'Critters' film to be rated R, all previous entries were rated PG-13.
Dee Wallace after 30 years of having participated in Critters (1986), retakes her character from Helen Brown however she declared that the character was renamed as Aunt Dee for legal reasons between Warner Bros. and the writer of the first film.
The first Critters movie to not star Don Keith Opper as Charlie, or Terrance Mann as Ug.
The first film since the original to credit the voice actors for the Crites.
When Drea suggested playing card games, one of the kids said, "What is this, 1986?" 1986 was the year of release for the original Critters.