The movie poster on the wall of Amy's house shows the director of the film 'Venefica' to be a Harry Darrow--a nod to Harry Darrow, the former art director of Law & Order: Criminal Intent. Darrow passed away on December 30, 2007. In an earlier episode--the seventh season finale--an "In Memory of" credit appears during the end credits.
In 2010 Purdue Pharma, the original manufacturer of OxyContin, stopped marketing their original formulation of OxyContin. They released a new formulation of OxyContin that was designed to be tamper resistant. In the past the extended release properties of OxyContin could be negated by simply smashing the tablet, which allowed the entire dose to be released at once, it also allowed it to be mixed with water and then injected intravenously. However the new formulation is coated with a type of polymer that makes the tablets very hard to crush, and when crushed the polymer sticks to the drug on the inside of the tablet, so even with the tablet smashed into tiny pieces it retains most of its extended release properties. Plus when this polymer is exposed to water it turns into a semi gelatinous state which makes it almost impossible for the oxycodone to be drawn up into a syringe. People naturally have found ways around these countermeasures but it has been successful in reducing the overall number of overdoses from OxyContin. However there are concerns about the effectiveness of this new formulation for people who legitimately use the drug for chronic pain. While the polymer coating does help to maintain the drug's extended release properties when abused there is also evidence that it works a little too well when the drug is taken as directed, in other words it is not releasing all of the medication inside the tablet thereby causing the patient to not get the full dose. Because of this and other reasons there is a new extended release formulation of oxycodone under development for use in the United States (there are already similar ones in use in Europe). This new formulation is a capsule instead of a tablet and contains a dozen or so small pellets inside, about 3/4 of the pellets contain oxycodone and the other 1/4 contain the opioid antagonist naloxone. Naloxone acts as an "antidote" for opioid overdoses and blocks their effects, it is absorbed very poorly in the digestive tract, but is absorbed very well when inhaled or injected. When the capsules are taken as directed the naloxone remains inactive, but if the pellets inside the capsule are smashed and the contents are inhaled or injected the naloxone blocks the effects of the oxycodone.
OxyContin is the brand name for the extended release formulation of the opioid analgesic oxycodone. One reason OxyContin is more deadly than other forms of oxycodone when abused is that is has a much larger dose. Immediate release (IR) oxycodone/acetaminophen tablets like Percocet contain either 2.5, 5.0, 7.5, or 10.0 milligrams. Oxycodone IR (tablets with oxycodone only that release all the medication at once) come in strengths of 5, 10, 15, 20, and 30 mg per tablet. Whereas OxyContin comes in strengths of 10, 20, 30, 40, 60, and 80 mg. When taken as directed, the OxyContin tablet slowly releases its dose over a period of 8 to12 hours depending on the person's metabolism. However, if the tablets are crushed and then used, then the dose is released at once: such use is very dangerous, especially with the larger strengths. Inhaling or injecting oxycodone further increases its potency: 80 mg of oxycodone taken intravenously equals approximately 110 mg taken orally--dangerous for anyone, but deadly for someone with little to no tolerance for opioids.
Glen Kennebragh is one of the many fictional scotch whiskys to be featured in film and TV land.