- She Blinded Me With Science(uncredited)Written by Thomas Dolby and Jo KerrPerformed by Thomas Dolby[Howard has an instrumental version of the song as his cell phone ringtone]
- History of Everything(uncredited)Written by Barenaked LadiesPerformed by Barenaked Ladies[Series theme song played during the opening titles]
- Main Title from Superman (Instrumental)(uncredited)Written by John WilliamsPerformed by Jim Parsons[Sheldon hums the tune when he's getting ready to go into his apartment with his dinner]
- Soft Kitty(uncredited)Performed by Kaley Cuoco[Penny sings the song to Sheldon when he can't fall asleep]
- History of Everything (Instrumental version)(uncredited)Written by Barenaked LadiesPerformed by Barenaked Ladies[Instrumental version of series theme song played over the closing credits]
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