Cooper Howard's fictional western film, "A Man and His Dog" is a reference to the Harlan Ellison short story "A Boy and His Dog", adapted as A Boy and His Dog (1975). The post-apocalyptic story of a boy and his psychic dog are a huge influence on the Fallout games, particularly the character of Dogmeat.
The series is set within the same continuity as the video game franchise but will be an original story. Executive producer Todd Howard said he wanted to avoid adapting the video games.
The town of "Filly" is called that because it is built upon a landfill. It has nothing to do with Philadelphia, PA.
The Vault Boy imagery, which originated in the video games, will have an origin story.
If you call the Vault-Tec number shown in the commercial (213) 258-2858 there is an interesting recording waiting for you.