Ashley Greene said it was fun playing Simone because she was so uninhibited.
Principal photography began on December 16, 2020 and concluded on January 26, 2021. The film had its world premiere at the Mammoth Film Festival on February 3, 2022. On February 18, Screen Media Films acquired the film's distribution rights and it was released in January 2023.
Ashley Greene's first nude scene was when she performed topless in the third season of the Rogue (2013) series. The Immaculate Room is her first full nudity.