During the Brotherhood's chase sequence with Guybrush, Bugeye shouts out, "Faster, minions! Kill! Kill!", which is a spoof on the movie's title "Faster, Pussycat! Kill! Kill!"
The scene where Guybrush switches the head of Santino with Murray's head is a parody of the scene where Indy exchanges the golden idol with a bag of sand in the prologue of this movie.