This was the first episode directed by Matthew Gray Gubler.
One of the locations Matthew Gray Gubler scouted for shooting, but didn't use, was later used as the eponymous building in "Heathridge Manor (2012)", another episode he directed.
Brooke Smith (Barbara Lynch), portrayed the victim of another serial criminal, Buffalo Bill in The Silence of the Lambs (1991).
When Sarah lists off the names and abduction details of the kids she's researched, she mentions that one of them is abducted from Rock Creek Park, which is a location of the eponymous Rock Creek Park (2015).