Looking at the title of the 5th episode of the 6th season, you have low expectations. However, I am very glad to say that the episode's title does not do any justice to the episode.
I expected Live Free or Twihard to be a spoof of the vampire saga going on at this time in 2010 (which would have been good), and while the first 10 minutes did hint jokes at it, it was otherwise a very serious episode (which was even better given the context of the show at this time). The episode was cleverly written, carefully directed, and had some really great cinematography. This was one of the most atmospheric episodes of the show I can remember, and while there have been a lot of great vampire episodes in the past, this was the best. It gave us a different world of the vampires, a more Gothic tone to it as opposed to completely dangerous. The episode was directed like a horror film. Along with that, the mystery surrounding Sam is still in the air, although a scene that shows us the character Sam has become does make us wonder what went wrong. And the bad thing is that Dean knows it, and it is painfully hurting him.
Overall, this was a very strong episode, with a unique tone to it that makes this season feel like it will be the darkest. The amazing thing is it is the best episode of the season yet, which I thought would be impossible after the episode before it Weekend at Bobby's.