The second film introduces many fantastical and science fiction elements that weren't present in the first film; such as cloning (Performed by Nozomi, who in the first film was only a nurse but can now clone full grown adults from dead tissue samples) and indestructible cyborgs.
Yui Aikawa portrayed Tomoe (Tomiya) in the first entry of the series, who was killed near the end of the film. She returns in this film as a different character: the American Cyborg.
Was shot back-to-back with Rape Zombie: Lust of the Dead 3 (2013), and premièred at the Theatre Shinjuku in Tokyo on a double bill with it.