Nick's character states "Oh, did you guys know Benjamin Franklin died of syphilis? Fact. He did." In fact: Benjamin Franklin died on April 17, 1790 when he was 84 years old. The cause of his death was empyema brought by attacks of pleurisy, which he had suffered earlier in his life. (Reference: Benjamin Franklin Historical Society) While he may have died WITH syphilis it was not the reason for his death.
The character Adam turns 24 years old at the start of the film. Several weeks later, towards the ending, Adam and Chris has a confrontation scene that goes like this
Chris : "Why did you not fucking tell me 20 years ago" Adam : " I was 3"
Well, you can do the math.
Chris : "Why did you not fucking tell me 20 years ago" Adam : " I was 3"
Well, you can do the math.
Around 1h:13m into the movie, Chris and Jess are circling around a mall parking lot to go to the Cheesecake Factory, where they find the Prius with two kayaks and the Save the Whales bumper sticker. The Cheesecake Factory is not located in the mall that they are in the parking lot of (Crossgates Mall), instead it is in another local mall (Colonie Center).
Jessica mentions to Chris that they have a reservation at the Cheesecake Factory. However, the Cheesecake Factory does not take reservations.