When Wynonna sees Eve for the first time, disguised as Wynonna herself, Eve begins a long speech about, basically killing all her family. Wynonna hearing all this, comments, "Jesus, 'Orphan Whack', take a midol and a nap." Wynonna is making reference to the TV show, Orphan Black (2013). Varun Saranga (Jeremy Chetri) made an appearance on the show, playing Neal.
The title for this episode "Friends in Low Places" is a country song by Garth Brooks