"Rescue Me" was released on June 15, 2018 through Interscope Records, as the third single from the album.
"Rescue Me" was described as a song exploring themes such as pain, empowerment, faith, and freedom.
The song was recorded at The International Centre for the Advancement of the Arts and Sciences of Sound in Los Angeles, California.
The band premiered the song on Vevo on March 30, 2018, one week before the album's release.
An earlier version of the song is performed by Jared Leto in the documentary film Artifact (2012).