Nikki Glaser is an American stand-up comedian, podcast host, and television host. She is currently hosting "You Up with Nikki Glaser".Nikki Glaser is an American stand-up comedian, podcast host, and television host. She is currently hosting "You Up with Nikki Glaser".Nikki Glaser is an American stand-up comedian, podcast host, and television host. She is currently hosting "You Up with Nikki Glaser".