MacGyver and his archaeologist friend continue on to London and France in their search for the Holy Rose. Along the way they come across a notorious jewel magnate who has deadly intentions.
A female defector, who is a witness to a murder, is protected by the Phoenix Foundation. She also holds the key to the location of a priceless necklace.
While in Geneva, MacGyver is wounded in an assassination attempt. He is framed as the sniper and meets an American schoolgirl who helps him in clearing his name.
Renegade America service men steal everything that's not nailed down in Thailand, creating a life-threatening situation. MacGyver helps set things right, while helping an old friend get acquainted with a son he never knew he had.
Murdoc enlists MacGyver's help to rescue his sister from his former employer. She is scheduled to be executed during a Halloween Party put on by the professional assassination organization.
MacGyver trails a friend, Billy Colton, to Africa where he witnesses the cruel slaughter of the endangered Black Rhino. When he joins the activists, hoping to prevent the poaching, Mac meets up with the men behind the scheme - Ladysmith.
A rock-star friend of MacGyver's is filming a video for the Rock Against Drugs campaign. A series of mysterious accidents that occur during filming convinces her that her twin sister is attempting to kill her.
Exhausted from being overworked, MacGyver falls asleep watching an old western. He dreams that he is in the Old West where he encounters Murdoc and Pete who conspire to force MacGyver off his land.
MacGyver is mentoring a troubled high school student who drops out of school to work at a construction site with his dad. While there, the kid discovers that the site may be unsafe when he witnesses a safety inspector being bribed.
A female scientist designs an innovative sonar detection system for the Phoenix Foundation. The shady owner of a submarine company wants to sell her system to a drug-smuggling cartel.
A famous musician is abducted by criminals who want a violin originally owned by Mozart as the ransom. A young woman enlists MacGyver's help to defeat the criminals.
MacGyver is serving as a sequestered member of the jury in a racially-charged trial. MacGyver sneaks out to investigate the crime scene, uncovering new evidence, but also landing him in contempt of court.
While in a coma resulting from a great fall, MacGyver has a near-death experience, where he is reunited with his grandfather Harry and his long-deceased parents.