With Ethan, Sir Malcolm and Dr. Frankenstein now scattered around the world facing their own demons, a shattered and despondent Vanessa seeks the help of Dr. Seward to battle a new evil.
Sir Malcolm continues on his journey with the enigmatic Kaetenay. Meanwhile, Ethan gets some unexpected help from Hecate, Drs. Frankenstein and Jekyll hatch a plan and unbeknownst to her, evil forces track Vanessa's every move.
Vanessa contacts her old friend Ferdinand Lyle for help. Lyle introduces her to Catriona Hartdegen. Lily, Dorian and Justine put their plan in motion. Ethan, Sir Malcolm and Hecate arrive at Talbot's ranch.