Desna launches Claws Up, her new multi-level Oxy sales operation, employing some of her most loyal clients as dealers and recruiters à la Mary Kay; tension rises for the crew as they attempt to manage a criminal enterprise from the top.
Desna and her crew begin to enjoy the benefits of their newfound success until it's discovered someone is stealing and reselling their pills under a different label.
Feeling guilty for Jenn and Bryce losing custody of their children, Desna offers them use of her condo, where Jenn begins secretly taking Oxy to steady her nerves.
Desna opens up a second nail salon, but a rival salon owner soon demands a monthly payoff; Jenn's Oxy addiction spirals out of control as she forms a suspiciously close bond with Tony.
Desna vows not to rest until she has dismantled Uncle Daddy's organisation from the inside out; Jenn's questionable friendship with Tony is discovered by both Desna and Bryce, threatening to destroy both relationships.
With the realization that Tony is a DEA agent, Desna must rally her crew to avoid being taken down by the feds. When Jenn overdoses, the crew begins to uncover buried truths that threaten to unravel their bond.
With the crew in shambles and the threat of the DEA looming, Desna plots an exit strategy for herself and her girls; her plans are accelerated after Bryce kills Tony in a jealous rage and then confesses it to Uncle Daddy.
Desna, the gangster queen of Palmetto, has her final showdown with nemesis and former friend, Quiet Ann. Desna must jump through hoops as she prepares the gangs evacuation from Palmetto.