During the COVID-19 pandemic, the staff of Chastain does their best to treat the overwhelming number of patients that they face while also trying to protect their loved ones; Conrad and Nic get married.
When Cain's elected surgery patient returns with complications, Mina and Raptor butt heads over how to handle the situation; Conrad and Devon treat a local Congresswoman.
When Cain tries to be a hero at a crash scene, he is struck by a car, causing Chastain's doctors to put aside their personal issues to try and save his life.
The staff works to diagnose a mother and daughter with a mysterious illness. Devon deals with a surprise visit from his mother. Mina makes a surprise proposal.
Chastain is being dismantled, Doctors and surgeons are transferring and patients are panicking. Nic and Conrad announce they're going to be parents when another tragedy strikes.
The hospital, now a public hospital, tries to adjust to the changes. When one of the surgeons who is scheduled to perform an important surgery decides to quit because of his pay reduction, they try to find another.
When Conrad gets a call from his former army commander who is stranded and wounded in the forest, the trip to save him brings lots of old emotions to the surface.
On Nic's first day back at Chastain, the man who attacked her is admitted to the ER, causing her to confront her trauma head-on. Cain, now in recovery, is self-conscious of his physical state and sets his eye on taking down Mina.
Conrad and Bell treats the woman carrying Jake's future baby. Devon contemplates his love life. Mina receives a call that causes her to make a bold decision about her future.
With Nic's due date steadily approaching, she and Conrad plan a relaxing day off, but their plans are interrupted when a patient with a medical mystery sends them rushing back to Chastain.